Having fewer ads on a 336×280 large rectangle seems to serve both
JenSense: Why are the large rectangle ad units showing two ads now instead of four? There has been a lot of discussion about this, particularly in regards to earnings.
AdSenseAdvisor: If you only see two ads in an ad unit appearing, it is because our technology has determined the publisher will receive a higher eCPM. This is an automatic optimization feature.
We think some of the reportedly lower earnings are probably seasonal. However, as always, people should email adsense-support@google.com if they feel there is a problem on their particular site.
This feature benefits Google as well. It now has a method for disrupting heavily blended ad layouts which may help bring down accidental clicks. With that much white space, only a true caveman clicker will fall for blended click traps.
BTW, the entire ad number selection process is automated, there’s nothing you can do from your end to ‘force’ adsense to display more ads on a single ad unit.